Ubiquitination is a crucial post-translational modification process that can degrade proteins within cells and plays a vital role in maintaining protein homeostasis and abundance.Deubiquitinating enzymes (DUBs) are important proteases in the ubiquitin system.They reverse the ubiquitination process by cleaving protein chains and SOAP 3 IN 1 UNSCENTED recycling ubiquitin molecules to regulate protein stability.
Abnormal deubiquitinating enzyme activity is related to the occurrence and development of many malignant tumors.JOSD2, a DUB, is a member of the Machado-Joseph disease protein domain protease (MJD) family and characterized by a single highly conserved catalytic Josephin domain.Increasing studies have revealed a connection between JOSD2 and malignant tumors.
This Rash Guards article elaborates on the current research status of DUBs, particularly JOSD2, in malignant tumors.Results suggest that JOSD2 is a potential target for the treatment of malignant tumors.